Treat Pain Caused by Osteoarthritis with nSTRIDE Autologous Protein Solution (APS)

SEMI is pleased to offer a new autologous therapy: nSTRIDE APS injections. This injection can treat pain and slow the progression of cartilage degradation and destruction associated with osteoarthritis.

How does nSTRIDE APS work?

nSTRIDE APS injections involve withdrawing 60 cc of a patient’s own blood. Next, the blood is processed in a centrifuge, which separates the blood and concentrates white blood cells, platelets, and plasma proteins into a small volume of plasma. This small volume of plasma contains a high concentration of anti-inflammatory (good) proteins including interleukin-1 receptor antagonist (IL-1ra), soluble interleukin-1 receptor (sIL-1R), soluble tumor necrosis factor receptor I and II (sTNF-RI and TNF-RII). These good proteins are designed to overwhelm and block the inflammatory (bad) proteins interleukin-1 receptor (IL-1) and tumor necrosis factor alpha (TNFα). Additionally, anabolic, or building, growth factors insulin-like growth factor-1 (IGF-1) and transforming growth factor beta 1 (TGF-β1) are also present in this solution to benefit cartilage health.

When are nSTRIDE APS Injections Used?

nSTRIDE APS injections are used for osteoarthritis, when the protective cartilage that cushions the ends of your bones wears down over time. Therefore they are injected directly into the joint under ultrasound guidance.

Are nSTRIDE APS Injections Guided by Ultrasound?

Most times, ultrasound guidance is needed to ensure accurate needle placement, and SEMI has the necessary ultrasound equipment to use when required.

How Many nSTRIDE APS Injections are Required?

Clinical studies have demonstrated the effectiveness of one injection, and may last as long as 24 months.

Is There Any Science on This Topic?

For an up to date reference list please go to, which is the US National Library of Congress website devoted entirely to published research on a multitude of topics. In the search window enter the topic you are interested in, such as nSTRIDE. This will return the currently published list of articles for your review.

For an up to date listing of international research projects on this topic currently underway, but not yet completed, please go to Again, in the search window, enter the same search string, and you will be given an up to date list of all such research projects